Abstract: The dose-effect and time-effect relationships of metallothionein(MT)were studied from the liver of mice injected with zinc and MT measured by cadmiumsaturation methods.It showed that there was a relation between the hepatic MT and zinc dose below the letal dose of mice.The hepatic MT of mice increased in 12 hours,decreased after 24 hours and reached normal level after 3 days.The more zinc,the more hepatic MT at certain scope of doses.