Abstract: To study pregnant women exposure to lead and its effect on fetus in Hubei,we selected 90 pregnant women from three un-similar districts,who had no know occupational exposure to heavy metals.Under strict quality control,the blood was obtained.The blood level was determined with Japan 180-80 flame atomic absorption spectrometer.The results showed:the geometric mean(GM)PbB of the 28 weeks of pregnancy(Y1) and delivery(Y2) was 0.290μmol/L and 0.326μmol/L,respectively.The GMPbB level of umbilical cord(Y3) is 0 333μmol/L(17.8% umbilical cord PbB>0.483 μmol/L).The correlation coefficient of Y3 and Y2 was 0.6805,P<0.01.Y3=0.12251067+0.16094591Y1+0.78077865Y2 by stepwise regress.But the lead level didn't cause adverse effects on fetal development.