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吕全军, 姚树样, 黄承钰, 兰亚佳, 姜勇, Phillip R. Taylor, 乔友林, 王瑞淑. 酒精摄入量与云锡(YTC)矿工肺癌的队列研究[J]. 中国公共卫生, 2000, 16(8): 707-708. DOI: 10.11847/zgggws2000-16-08-21
引用本文: 吕全军, 姚树样, 黄承钰, 兰亚佳, 姜勇, Phillip R. Taylor, 乔友林, 王瑞淑. 酒精摄入量与云锡(YTC)矿工肺癌的队列研究[J]. 中国公共卫生, 2000, 16(8): 707-708. DOI: 10.11847/zgggws2000-16-08-21
The Cohort Study on Intake of Alcohol and Lung Cancer Risk in the Yunnan Tin Corporation(YTC)Miners[J]. Chinese Journal of Public Health, 2000, 16(8): 707-708. DOI: 10.11847/zgggws2000-16-08-21
Citation: The Cohort Study on Intake of Alcohol and Lung Cancer Risk in the Yunnan Tin Corporation(YTC)Miners[J]. Chinese Journal of Public Health, 2000, 16(8): 707-708. DOI: 10.11847/zgggws2000-16-08-21

酒精摄入量与云锡(YTC)矿工肺癌的队列研究

The Cohort Study on Intake of Alcohol and Lung Cancer Risk in the Yunnan Tin Corporation(YTC)Miners

  • 摘要: 为了解酒精摄入量与云锡(YTC)矿工肺癌危险性的关系,在食物频率问卷(FFQ)资料中饮酒重复性和有效性研究的基础上,计算出云锡矿工肺癌高危人群酒精摄入量;用χ2检验、单因素、多因素Cox回归分析了云锡矿工肺癌高危人群不同酒精摄入量与其发生肺癌相对危险性的关系.结果表明:酒精摄入量与云锡矿工肺癌发病率呈“J形”关系,即不饮酒和中等量以上饮酒者(酒精摄入量≥50g/d),肺癌发病率显着高于少量饮酒(酒精摄入量0~50g/d)(P<0.01);少量饮酒与肺癌相对危险性呈负相关(RR<1,P<0.05):大量饮酒(酒精摄入量≥100g/d)与肺癌相对危险性呈正相关(RR>1,P<0.01);经调整年龄、工龄、吸烟后,没有发现少量饮酒对矿工肺癌患者具有保护作用,酒精摄入量大于50g/d即显示与肺癌相对危险性呈正相关(RR>1,P<0.01),说明饮酒可能是云锡矿工肺癌发生的危险因素,且可能与职业危险因素有协同作用.

     

    Abstract: The relationship between alcohol intake and lung cancer risk was studied among the Yunnan Tin Corporation(YTC)miners.On the basis of the reproducibility and validity of Food Frequency Questionnaire(FFQ),the alcohol intake was calculated and the correlation between the different intake of alcohol and relative risk of lung cancer in population with lung cancer athigh risk was analyzed by means of Chi-square,Cox regression model.The results show that there are significantly different incidence of lung cancer among subjects consuming different levels of alcohol(P<0.01);"J shape" correlation was found,i.e.the incidences of lung cancer of non drinkers and more than medium drinkers(intake of alcohol ≥50 g/d)is significantly higher incidence than that of light-drinkers(intake of alcohol 0~50g/d);light-drinkers are significantly negative correlation with lung cancer risk(RR<1,P<0.01);heavy-drinkers(intake of alcohol≥100g/d)are significantly positive correlation with lung cancer risk(RR>1,P<0.01);after adjusting confounders such as age,occupational history and smoke,medium and heavy-drinkers are significantly positive correlation with lung cancer risk(RR>1,P<0.01).It can be considered that alcohol is a risk factor to develop lung cancer at YTC and may have synergic effects with occupational risk factors.

     

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