Abstract: Objective To observe the effect of anti-endotoxin drug-glycine in endotoxemialed by heat stroke.Methods Twenty-four rats were randomly divided into three groups,two groups with heat exposure were given glycine(G)and 0.9% saline (NS),respectively.Normal control(NC)group was exposed to room temperature.Results(1)heat shock time:Ggroup 88.3± 315 min,NS group 79.5±4.2min;survival time(interval between onset of heat shock and death):G group 35.5±4.4min,NS group 18.0±4.5min.There is a significant difference between each group(P<0.01).(2)the rectal temperature(Tr),heart rate,men arterial pressure after heat exposure were:G group 42.5±0.4℃、 459±9.9 beats/min,11.5±0.8kPa;NS group 43.1±0.4℃、 483.3±9.4 beats/min、9.3±0.8kPa;NC group 37.1±0.3℃、 360.8±10.6 beats/min、13.5±1.3kPa respectively.Ther e are significant differences among each group(P<0.05).Conclusion G plays an important role in resisting endotoxemialed by heat exposure.