Abstract: Objective To screen the risk factors relating with psychological problems of college students.Methods With 1:2 matched case-control study,the students from a college completed psychological questionnaire and EPQ scales.Univariate and multivariate 1:2 matched logistic regression analyses are used to analyse the difference between case and control groups.Results Univariate analysis result shows that 13 factors are significantly relative to psychological problems.And 7 factors of them are significantly(P<0.05)to multivariate analysis.Conclusion The relationship between the students and their family members,the style of speaking out feeling in trouble,family income,the degree of the parents' expectation to the students' study,social life events,the style of leisure time activity,and perso nality are main risk factors resulting in psychological problems of college students.