Abstract: Objective To observe the effect of glucose acid chromium on rat body weight,level of serum leptin and serum growth hormone.Methods　Eight groups of rats were randomly fed with different diets(basal diet,high-fat diet),different levels of glucose acid chromium for 8 weeks.All rats were weighed once a week.At the end of the experiment,all animals were decapitalized and their blood samples were taken and the concentration of serum leptin and growth hormone were tested by RIA method.In the meantime,the liver,the spleen,the kidneys and the testis were isolated and weighed,the ratio of internal organs to the body weight were calculated.Results　Glucose acid chromium can cause weight loss slightly,improve the phenomenon of diet incduced "Leptin resistance",increase the secretion of growth hormone.