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孙贵范, 刘珊, 李冰, 李昕, 郭晓英, 孙鲜策. 正常成人尿中8-羟基脱氧鸟苷水平的观察[J]. 中国公共卫生, 2002, 18(1): 23-24. DOI: 10.11847/zgggws2002-18-01-12
引用本文: 孙贵范, 刘珊, 李冰, 李昕, 郭晓英, 孙鲜策. 正常成人尿中8-羟基脱氧鸟苷水平的观察[J]. 中国公共卫生, 2002, 18(1): 23-24. DOI: 10.11847/zgggws2002-18-01-12
SUN Gui-fan, . Observation on 8-OHdG Level in Urine of Normal Adults[J]. Chinese Journal of Public Health, 2002, 18(1): 23-24. DOI: 10.11847/zgggws2002-18-01-12
Citation: SUN Gui-fan, . Observation on 8-OHdG Level in Urine of Normal Adults[J]. Chinese Journal of Public Health, 2002, 18(1): 23-24. DOI: 10.11847/zgggws2002-18-01-12

正常成人尿中8-羟基脱氧鸟苷水平的观察

Observation on 8-OHdG Level in Urine of Normal Adults

  • 摘要: 目的检测正常成人尿中8-羟基脱氧鸟苷(8-OHdG)水平,了解其在正常人群中的分布范围.方法用8-OHdG的酶联免疫试剂盒检测尿中8-OHdG水平,用苦味酸法测定尿中的肌酐,计算8-OHdG的肌酐校正值.结果正常人群尿中8-OHdG水平为14.15±9.00ng/mgCr.在不同性别间存在显着性差异,男性为11.85±5.72ng/mgCr,女性为16.24±10.83ng/mgCr.按10岁一个年龄段分层,在男性、女性和全体人群中各年龄组间均无显着性差异.女性在21~60岁年龄段8-OHdG水平有随年龄增加而增高的趋势.结论正常人群8-OHdG水平的95%参考值范围在男女性分别为0~25.77ng/mgCr和0~44.89ng/mgCr.

     

    Abstract: ObjectiveTo detect the level of 8-OHdG in urine of normal adults and estimate its range in normal population.MethodsEL ISA kits for 8-OHdG check are used to detect 8-OHdG in urine samples.Picrate method is used for creatine detection.8-OHdG level is adjusted by creatine in urine.ResultsThe average level of 8-OHdG in urine of normal population is 14.15±9.00ng/mgCr.There is significant difference between males and females,and the levels are 11.85±5.72ng/mg·Cr and 16.24±10.83ng/mg·Cr respectively.The whole population is stratified by every 10 years old,and no significant difference is observed among the stratums in males,females as well as the total.In females aged 21-60,the level of 8-OHdG increases with age.ConclusionThe 95% reference ranges of 8-OHdG in urine of normal males and females are 0-25.77ng/mg·Cr and 0-44.89ng/mg·Cr respectively.

     

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