Abstract: ObjectiveTo grasp HFRS's prevalent regularity in whole province,to control its outbreak and to work out the way to deal with it.MethodsTo use direct fluorescent antibody technic(FAT)to test HVant igen in rat's lung,use indirect fluorescent antibody technic(TFAT)and Mac ELTSA to test HV antibody in serum of patient and people in good health.ResultsThere were 96 188 patients in whole province from 1995 to 2000,and 345 of them died.The average morbidity was 18.38 per 100 000 persons and mortality was 0.36 percent.Most patients were in the middle-south hilly land and Jiaolai plain of Shandong province.One hundred and thirty six conuties of 17 cities of Shandong province had patients.The patients were both disperse and relatively concent rately.Sixty one point seventy three percent of patients came from Linyi、Rizhao、Jinan、Taian and Zibo city.Most HFRS's host animal in field was Apodemus agrarius Pallas and Rattus norveg icus Berkenhout,most host animal in the house was Rattus norvegicus Berkenhout.ConclusionHFRS's surveillance and vaccinating people with HFRS's vaccine must be enhanced.