紫外线照射对小鼠肝、肾羟脯氨酸含量影响的实验研究

Experimental Study on Effects of Ultraviolet Exposure on Hydroxyproline Content of Moue’s Liver and Kidney

摘要: 目的研究紫外线全身照射对脏器羟脯氨酸含量的影响。方法无毛小鼠长期接受全身紫外线照射后测定肝、肾羟脯氨酸含量。结果肝脏羟脯氨酸含量增高,丁羟甲苯及烟酰胺对此无保护作用,肾脏羟脯氨酸含量无明显变化,丁羟甲苯及丙酮可使肾脏羟脯氨酸含量轻度增高。结论紫外线长期照射及某些皮肤“保护剂”(或其溶剂)可影响脏器胶原代谢,值得注意。

Abstract: Objective To study the effect of chronic whole body ultraviolet exposures to organ hydroxyproline content.Methods To determinate hydroxyproline content of liver and kidney after chronic whole body ultraviolet exposures of hairless mice.Results Liver hydroxyproline content elevated and butylated hydroxytoluene or nicotinamide showed no protection.No significant effect on kidney hydroxyproline but butylated hydroxytoluene and acetone cause slight increase of kidney hydroxyproline.Conclusion The effects on collagen metablism of internal organs by chronic UV exposure and some sun2burn protectants should not be ignored and needed further study.