Abstract:
Objective To explain apoptosis induced by cadmium chloride in 293 cells in vitro.
Methods 293 cells were exposed to 0,12.5,25.0,50.0μmol/L of CdCl
2 for various time period,to measure the apoptosis by DNA agarose electrophoresis and ELISA.
Results CdCl
2 could induce apotosis of 293 cells in vitro at concentration of 12.50,25.00,50.00μmol/L.Different concentration of CdCl
2 could also cause reduction of cells survial associated with exposed doses and time and apoptosis.
Conclusion Cadmium chloride coucld induce 293 cell apoptosis in vitro associated with exposed dose and time.