Abstract: ObjectiveTo study on the change of humoral and cellular immune of HBV carriers.Methods50 HBV carriers were screened by ELISA,whose HBsAg were positive and the indexes of liver functions are normal;IgG,IgA,IgM,IgE in serum were detected by immune globins detection kits and the subg roups of Timmune cell detected by APAAPmethod.ResultsThe levels of IgG,IgA,IgM of HBV carrier were significant lower than those of the no rmal control group(P<0.05), and the difference of IgE level was not significant.The levels of CD₃⁺ and CD₈⁺ were all significanthigher than those of the normal control group(P<0.01),however the CD₄⁺/CD₈⁺ was lower than that of the nor mal group(P<0.05).ConclusionThe humoral immune of HBV carriers was lower.HBV virus can stimulate the proliferation of CD₄⁺ and CD₈⁺,and lead to the function of celluar immune disorder.