Abstract: Objective This study investigated the effect of taurine on serum and liver cholesterol levels,and its mechanism in hypercholesterolemic rats.Methods Female weanling SD strain rats(80～100g),were divided into five groups,eight rats per group.As the control groups,Group A and B were fed either the high-cholesterol diet or normal diet.Group C、D、 and E were given one of the high-cholesterol diets incorporated with taurine at the levels of 0.6% 、1.35% or 3% respectively.The experiment lasted five weeks.Results All levels of taurine could significantly lowered the cholesterol levels of rats,buthigh level of taurine was more profound.0.6% level of taurine significantly increase plasma HDL-C、Apo-AI and lowed plasma Apo-B;1.35% an 3% levels of taurine significantly lowered TC、LDL-C、TG levels in plasma,increased the amount of fecal bile acids and ratio of HDL-C/LDL-C;effection of taurine at 3% level was more better.Conclusion Taurine have good effection on lipid metabolism in hypercholesterlomic rats.