Abstract: Objective To observe variations of serum lipid levels in response to a high monounsaturated fatty diet containing almond.Methods A self-controlled design was used in the experiment with eighty-five hyperlipidemia patients.During the experimental phase,75g almond per day was administrated for 4 weeks.Serum total cholesterol(TC),high-densitylipoprotein cholesterol(HDL-C),triglyceride(TG),apolipoprotein A_I and apolipoprotein B(ApoB)were determined at 0,4,8 week.Results After the treatment,TC and ApoB were decreased significantly in total subjects while Apo A_I increased.This healthy effect seemed more obvious in Type Ⅱ hyperlipidemia patients,and low-density-lipoprotein cholesterol(LDL-C) also decreased significantly.Moreover,the lowering effect of lipids last at least 4 weeks.Conclusion Almond had healthy effect on serum lipids and apolipoproteins in hyperlipidemia patients.