Abstract: Objective To study the effect of pantothentic calcium on lipid perox idation in starved rat's brain.Methods To inject pantothentic calcium intragastricly to starved rats,then to examine brain MDA,GSH content and the activity of GSHPx and SOD at different fasting period.Results Lipid peroxidation MDA content increased markedly after fasting,however MDA content in suplemented straved rats rose no significantly compared with normal rats at four and seven days of fasting,and had marked discrrepancy compared with starved control groups.Pantothenic calcium had no apparent effects on the activities of SOD,GSH-Px,and significantly enhanced GSH levels in the starved rats which were significantly low than that before fasting.Conclusion Pantothenic calcium can protect rats from harmful lipid peroxidation and some of the mechanisms was probably due to enhancing the level of GSH.