Abstract: Objective To study the relationship between genetic polymorphism of Glutathione S-transferase M1,T1,P1 and susceptibility to hepatocellular carcinoma(HCC).Methods The genetic polymorphisms of GST M1,T1 and P1 of 84 patients with HCC and 144 healt hycontrols were detected by PCR.Results The frequencies of GSTM1 null genotype and GST T1 null genotype of cases were 66.67% and 40.48% respectively,while those of controls were 47.92% and 25.00% respectively.The differences were statistically significant(P<0.05);The frequencies of 3 genotypes for GSTP1 in cases were 64.29%,33.33% and 2.38% respectively,while those of controls were 61.80%,34.03% and 4.17% respectively.The differences were not statistically significant.Their odds ratio were 2.20,1.93 and 0.94 respectively after adjusting the sex.The individuals with GSTM1 null genotype and GSTT1 null genotype jointly increased the risk for HCC signiticantly.Conclusion GSTM1 and GSTT1 genes were useful indicates for screening the high risk population of HCC.