Abstract: Objective To research the influence of temperatare and cold air on the deaths and mortality of cardio and cerebral vascular disease(CVD)in Wuhan,and to indicate the preventive measures.Methods That 1 220 dead cases from CVD from 1991 and 1998(exclude 1995)were analyzed in Wuhan to describe and analyze the relationship between the deaths mortality of CVD and monthly average temperature,cold air.Results The deaths of CVD shows a dominant peak in J anuary and a second peak in July.Simple correlation analysis shows a positive correlation between temperature and the monality of CVD in summer:correlation coefficient is no significance in group 1(aging from 45 to 65years)(P>0.05),correlation coefficient is significance in group 2(age at≥65years)(P<0.05);and a negative in other seasons:correlation coefficients are significance in group 1 and group 2(P<0.05).The regression equation for temperature and the mortality of CVD in summer,Y= 0186 T-7.154(P<0.05)(for group 2),and in other seasons,Y=6.175-0.125 T(P<0.05)(for group 1),Y=24.5801415 T(P<0.05)(for group 2).Cold air slightly affects the deaths of CVD comparing with their distribution chart.Simple correlation analysis showed that the correlation coefficient is no significant between cold air and the mortality of CVD.Conclusion There is a positive correlation between temperature and the mortality of CVD in summer,and a negative one in other seasons.