非吸烟女性肺癌与月经生育史病例对照研究

尹智华; 李鸣川; 何钦成; 周宝森

doi:10.11847/zgggws2005-21-12-26

非吸烟女性肺癌与月经生育史病例对照研究

A case-control study on relationship between lung cancer in non-smoking women and menstrual and reproductive factors

摘要

摘要:
目的探讨月经史、生育史及避孕药的使用与非吸烟女性肺癌的关系。
方法对沈阳市区内非吸烟女性肺癌进行病例对照研究, 共收集了新诊断的非吸烟原发性肺癌病例409例及按配比年龄与性别在一般人群中选对照436例。调查内容包括人口特征、月经史、生育史以及避孕药服用史。用Logistic回归模型分析危险因素。
结果妊娠总数大(趋势检验P=0.018)、绝经年龄大(趋势检验P=0.065)的非吸烟女性, 肺癌发生的危险性大。使用口服避孕药可增加肺癌发生的风险, 其OR值为1.56(P=0.05)。
结论雌激素可能在非吸烟女性肺癌发生中起一定作用。

Abstract:
Objective To explore the endocrine factors and risk of lung cancer among non-smoking women.
Methods A case-control study on lung cancer was carried outin 18 hospitals of Shenyang, including 409 female cases and 436 female population controls matched by age within two years.Information on various menstrual and reproductive factors and use of oral contraceptives was gathered through personal interviews using a structured questionnaire.The risk factors were analyzed by logistic regression model.
Results An increasing risk of lung cancer was observed with high number of dilieries(trend test P=0.018)and later ages at menarche(trend test P=0.065).Moreover using of oral contraceptives would increase the risk of lung cancer and OR was 1.56(P=0.05).
Conclusion Female hormones are considered to play an important role in devel opment of lung cancer in non-smoking women.

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