内皮型一氧化氮合酶基因与年龄、吸烟的交互作用

宁艳; 贾崇奇; 刘同涛; 刘兆兰

doi:10.11847/zgggws2006-22-02-37

内皮型一氧化氮合酶基因与年龄、吸烟的交互作用

Interaction between endothelial nitric oxide synthase gene mutation and age, smoking in coronary heart disease

摘要

摘要:
目的探讨内皮型一氧化氮合酶(eNOS)基因第7外显子G 894 T(Glu 298 Asp)变异与年龄、吸烟之间交互作用在冠心病患病中的意义。
方法用病例—病例研究设计, 以新诊断的冠心病患者为研究对象, 用聚合酶链反应—限制性片段长度多态性分析法(PCR-RFLP)检测eNOS基因G 894 T变异, 运用单因素及多因素Logistic回归分析eNOS基因G 894 T变异与年龄、吸烟之间的交互作用。
结果 eNOS基因G 894 T变异与年龄之间在冠心病的患病中存在显著的相乘模型交互作用, 且该交互作用具有显著的剂量-反应关系; eNOS基因G 894 T变异与吸烟之间在冠心病的患病中无显著的相乘模型交互作用, 其交互作用也无显著的剂量-反应关系。
结论 eNOS基因G 894 T变异可增加低年龄者冠心病的患病的患病危险性; 且年龄越低, eNOS基因G 894 T变异对冠心病的患病危险性越高。

Abstract:
Objective To investigate the effect of interacion between endothelial nitric oxide synthase(eNOS)gene G894 Tmutation and age, smoking on the risk of coronary heart disease(CHD).
Methods Case-only design was used.Newly diagnosed CHD patients were recruited as subjects and polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP)was performed to detecteNOS gene G894 Tmutation.Interaction betweeneNOS gene G894 Tmutation and age, smoking was evaluated by odds ratios from simple and multiple logistic regression analysis.
Results There was significant negative multiplicative model interaction betweeneNOS gene G894 Tmutation and smoking, nor was the dose-response relationship significant.
Conclusion eNOS gene G894 Tmutation can lead to increased risk of CHD in younger groups, and the younger, the higher is the risk.

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