Abstract:
Objective To compare the immunotoxicity and genotoxicity of different ornamental materials in mice.
Methods The animals were exposed to the model cabinets ornamented with materials of good or poor quality 3 hours everyday for 4 weeks.At the 2nd, 7 th, 14 th and 28 th day, immunotoxicity was measured with macrophage swallow assay, and plaque formation assay and genotoxicity was measured with micronucleus assay.
Results The volatilization of ornamental materials of both good and poor quality induced the abnormality of macrophage swallow, caused a decrease of the number of plaque form cells, caused a decrease of body weight, thymus and spleen weight and the number of periphery white blood cells.The number of plaque form cells was lower in the exposed groups than that in the control groups.An increase of micronucleus rate was observed in exposure groups.The toxicities induced by ornamental materials of both good quality were more obvious and protracted.
Conclusion It is feasible to use the biomarkers of immunotoxicity and genotoxicity for the evaluation of ornamental materials.Both chemical and biological evidences are needed to estimate the security of ornamental materials.
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