淋巴细胞表面CCR5在HCV与HIV感染中表达

Expression of lymphocyte surface CCR5 in HCV and HIV infection

摘要:
目的探讨T淋巴细胞表面C-C趋化因子受体5(CCR5)在丙型肝炎病毒(HCV)感染、人类免疫缺陷病毒(HIV)感染和HCV/HIV合并感染过程中的表达及意义。
方法采用流式细胞术检测HCV感染组(n=21例), HIV感染组(n=14例), HCV/HIV感染组(n=28例)及正常对照组(n=30例)人外周血CD4+和CD8+T淋巴细胞表面CCR5的表达。
结果与正常对照组相比, 外周血CD4+和CD8+T淋巴细胞表面CCR5, HIV感染组高表达(P < 0.01), HCV感染组和HCV/HIV合并感染组中低表达(P < 0.01)。
结论淋巴细胞表面CCR5的表达, HIV感染时升高、HCV感染时降低, HCV/HIV合并感染时HCV感染的作用更强。

Abstract:
Objective To investigate expression and significance of CC-chemokine receptor 5(CCR5)in HCV monoinfection, HIV mono-infection and HCV/HIV co-infection.
Methods The surface expression of CCR5 on CD4+ Tcells and CD8+ Tcells from PBMC isolated from HCV infection(n=21), HIVinfection(n=14), HCV/HIV co-infection(n=28)and normal control(n=30)by flow cytometry.
Results The expression of CCR5 on CD4+ and CD8+ T lymphocytes increased significantly in HIV mono-infection(P < 0.01), but decreased significantly both in HCV mono-infection and HCV/HIV co-infection(P < 0.01).
Conclusion The surface expression of CCR5 on lymphocytes increased with HIV infection, decreased with HCV infection.In HCV/HIV co-infection, HCV maybe effect on the expression of CCR5 on lymphocytes.