乙醛脱氢酶2基因多态性及环境暴露与胃癌易感性

杨玉凤; 沈孝兵; 张娇

doi:10.11847/zgggws2006-22-04-34

乙醛脱氢酶2基因多态性及环境暴露与胃癌易感性

Relationship between ALDH2 genetic polymorphisms and environmental exposure and susceptibility to gastric cancer

摘要

摘要:
目的探讨乙醛脱氢酶2(ALDH2)基因多态性及环境暴露与胃癌易感性的关系。
方法采用1:1配对病例-对照研究和扩增产物长度多态性(APLP)方法, 检测南京市169例原发性胃癌患者和对照的ALDH2基因型, 分析其在胃癌发生中的作用; 结合环境危险因素分析, 对ALDH2基因多态性与环境危险因素在胃癌发生中的交互作用进行分析。
结果 ALDH2基因型在病例组和对照组分布差异有统计学意义(χ ²=4.617, P=0.032)。消化道疾病史、腌制食品、三餐不定时、暴饮暴食4项因素与胃癌发生的危险性增加有关; ALDH2基因与消化道疾病史、三餐不定时及暴饮暴食存在一定的交互作用。
结论 ALDH2基因多态性与胃癌易感性有关, 并与环境暴露有一定的交互作用。

Abstract:
Objective To evaluate the association between(ALDH2)genetic polymorphisms and some risk factors and susceptibility to gastric cancer in Nanjing population.
Methods PCR-Amplified product length polymorphism(PCR-APLP) technique were used to analyze the genetic polymorphisms of ALDH-among 169 cases of gastric cancer and a control group of cancer-free and matched by age(±5 years)and sex.Each subject was asked to answer a questionnaire about epidemiology of gastric cancer and was phlebotomized to test association between the interaction of ALDH-genetic polymorphisms and some risk factors and susceptibility to gastric cancer.
Results There was significant difference of the frequency of ALDH-genotypes between case group and control group(χ ²=4.617, P=0.032).Cigarette smoking, bloat food, having meals indefintely, engorgement was significantily associated with gastric cancer susceptibility.
Conclusion The genetic polymorphisms of ALDH-might contribute to gastric cancer susceptibility and interact with environmental exposure.

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