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于秋红, 黄沛力, 张淑华, 王辉. 山楂叶提取物抗氧化作用[J]. 中国公共卫生, 2006, 22(4): 463-464. DOI: 10.11847/zgggws2006-22-04-54
引用本文: 于秋红, 黄沛力, 张淑华, 王辉. 山楂叶提取物抗氧化作用[J]. 中国公共卫生, 2006, 22(4): 463-464. DOI: 10.11847/zgggws2006-22-04-54
YU Qiuhong, HUANG Peili, ZHANG Shuhua, . Study on anti-oxidation effects of hawthorn leaves[J]. Chinese Journal of Public Health, 2006, 22(4): 463-464. DOI: 10.11847/zgggws2006-22-04-54
Citation: YU Qiuhong, HUANG Peili, ZHANG Shuhua, . Study on anti-oxidation effects of hawthorn leaves[J]. Chinese Journal of Public Health, 2006, 22(4): 463-464. DOI: 10.11847/zgggws2006-22-04-54

山楂叶提取物抗氧化作用

Study on anti-oxidation effects of hawthorn leaves

  • 摘要:
      目的   探讨山楂叶提取物的抗氧化作用。
      方法   选用Wistar雄性大鼠, 在使用高脂饲料喂养的同时, 灌喂高、中、低3种不同剂量的山楂叶提取物, 4周后采血测定大鼠血清中超氧化物岐化酶(SOD)、谷胱苷肽过氧化物酶(GSH-Px)、血清LDL-C中维生素E、荧光物质的强度F和丙二醛(MDA)含量。
      结果   灌喂山楂叶提取物高、中、低剂量的各组大鼠血清SOD与高脂对照组比较, 差异无统计学意义(P > 0.05), GSH-Px值均高于高脂对照组(P < 0.05), 各组LDL-C中维生素E含量与高脂对照组相比均有所增加(P < 0.05)。山楂叶高、中剂量组荧光物质强度小于高脂对照组荧光物质强度(P < 0.05)。山楂叶各组MDA值与高脂对照组相比差异无统计学意义(P > 0.05)。
      结论   山楂叶提取物能增加大鼠血清中GSH-Px活性, 降低LDL-C中维生素E的消耗, 减少荧光物质的产生, 对低密度脂蛋白的氧化修饰有抑制作用, 具有抗氧化作用。

     

    Abstract:
      Objective   To study the effects that leaf of hawthorn restrain low-density lipopr otein C(LDL-C)oxidization.
      Methods   This paper has chosen wister male rates as the object.While the rats were fed with high-fed stuff everyday, they were also fed with hawkthorn leaves, in high, medium and low doses respectively.After four weeks.obser vation, the levels of superox ide dismutase(SOD), glutathione-Px(GSH-Px)mid Vitamin E, malonyl dialdehyde(MDA)and fluoresceuce in LDLC were studied.
      Results   The levels of SOD in each groups showed no significantly difference(P > 0.05), The levels of GSHPx in each leaf of hawthorn groups increased than that in high fat control group(P < 0.05).Vitamin E in high, medium and low doses groups showed significantly higher than that in high fat control group(P < 0.05).The levels of fluorescence in high doses groups, medium doses groups decreased compared with the level of high fat control group(P < 0.05).There were no significantly difference in each leaf of hawthorn groups and high fat control group(P > 0.05).
      Conclusion   Leaf of hawthorn has the capacity of decreasing the content of fluorescence; decreasing the consume of Vitamin E in LDL-C; restraining LDL-C oxidization increase; and it has the capacity of anti-oxidation effects.

     

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