修复酶基因多态性与食管癌易感性关系

张文翠; 尹立红; 浦跃朴; 刘冉; 胡旭; 刘耀珍; 崔永生

doi:10.11847/zgggws2006-22-05-31

修复酶基因多态性与食管癌易感性关系

Relationship between polymorphisms of DNA repair genes and esophageal cancer susceptibility

摘要

摘要:
目的研究DNA修复基因-着色性干皮病基因A(XPA)、着色性干皮病基因D(XPD)、X线修复交叉互补基因1(XRCC1)和X线修复交叉互补基因3(XRCC3)多态性与食管癌易感性的关系。
方法通过1:1配对的病例-对照研究方法收集样本106对, 应用PCR-限制性片断长度多态性(PCR-RFLP)技术检测样本的基因型, 比较不同基因型与食管癌易感性的关系。
结果携带XPAG/G基因型的个体与携带A/A基因型者相比, 可降低患食管癌的危险性(OR=0.473 7, 95%CI=0.228 0~0.983 9);食管癌组中, 携带XRCC1 399Gln/Gln的个体数高于对照组, 其患食管癌的危险性是对照人群的3倍(OR=3.447, 95%CI=1.078~11.026, P=0.029)。
结论 DNA修复基因XPA 23位和XRCC1 399位多态可能在食管癌的发生中起一定作用。

Abstract:
Objective To explore the relationship between the polymorphisms of XPA(A23G), XPD(Lys751 Gln), XRCC1(Argl94 Trp and Arg399Cln)and XRCC3(Thr/Met)genotypes and susceptibility to esophageal cancer in Huaian Han population, China.
Methods A 1:1 case-control study was conducted among 106 ESCC patients and 106 control subjects (matched by age±5 years and gender).PCR2RFL P method was used to detect genotypes.
Results There was significant difference of distribution of mutanthomozgote of XPA 23 and XRCC1 399 genotype between cases and controls(χ²=4.027 7, P=0.044 8;χ²=4.745, P=0.029, respectively).Individuals with mutant allele of XPD751, XRCCI194 or XRCC3241 genotype did not show the rising risk of esophageal cancer(OR=1.424, 95%CI=0.621~3.263;OR=0.826, 95%CI= 0.857~1.381;OR=1.276, 95%CI=0.483~3.371, respectively).
Conclusion The polymorphisms of XPAA23G and XRCC1 Arg399 Gln were related to the susceptibility of esophageal cancer in Huaian Han population.

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