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焦炳欣, 谢尧, 赵辉, 李娟, 石磊, 郭杰, 关小平. HBeAg阴性乙肝患者血清前S1抗原检测分析[J]. 中国公共卫生, 2006, 22(7): 851-852. DOI: 10.11847/zgggws2006-22-07-50
引用本文: 焦炳欣, 谢尧, 赵辉, 李娟, 石磊, 郭杰, 关小平. HBeAg阴性乙肝患者血清前S1抗原检测分析[J]. 中国公共卫生, 2006, 22(7): 851-852. DOI: 10.11847/zgggws2006-22-07-50
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JIAO Bingxin, XIE Yao, ZHAO Hui, . Analysis on Pre-S1 antigen test in serum of patients with HBeAg(-) chronic hepatitis B[J]. Chinese Journal of Public Health, 2006, 22(7): 851-852. DOI: 10.11847/zgggws2006-22-07-50
Citation: JIAO Bingxin, XIE Yao, ZHAO Hui, . Analysis on Pre-S1 antigen test in serum of patients with HBeAg(-) chronic hepatitis B[J]. Chinese Journal of Public Health, 2006, 22(7): 851-852. DOI: 10.11847/zgggws2006-22-07-50
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HBeAg阴性乙肝患者血清前S1抗原检测分析

Analysis on Pre-S1 antigen test in serum of patients with HBeAg(-) chronic hepatitis B

    摘要
  • 摘要:
      目的   探讨HBeAg阴性乙肝患者血清前S1抗原检测的意义及应用价值。
      方法   用ELISA方法对314例慢性乙型肝炎患者血清进行前S1抗原的测定并对其HBV-DNA含量进行分析研究。分析170例HBeAg阴性乙肝患者和144例HBeAg阳性的乙肝患者血清中HBV-DNA的含量。
      结果   在170例血清HBeAg阴性患者中, 60%为PreS1阳性, 其阳性率显著低于144例HBeAg阳性患者, PreS1阳性检出率为76%(χ2=9.55, P < 0.005)。在212例PreS1阳性标本中, HBV-DNA阳性检出率为94%, 其病毒载量(log)为5.78±1.94, HBV-DNA阳性率和HBV-DNA病毒载量均显著高于PreS1阴性患者(102例)HBV-DNA阳性率为82%(χ2=11.45, P < 0.005)和病毒载量(log)4.35±2.33, (t=5.36, P=0.000 1)。在HBeAg阴性患者中, 90%的PreS1(+)者为HBV-DNA阳性, 其病毒载量为(log)4.89±2.00, 显著高于PreS1阴性患者的HBV-DNA阳性检出率(75%)(χ2=7.52, P < 0.01), 和病毒载量(log)37.7±2.46(t=3.13, P=0.002)。
      结论   乙肝病毒前S1抗原的检测能敏感的反映乙肝病毒的复制, 当HBeAg阴性时PreS1阳性可预测血清HBV-DNA的状态, PerS1检测具有重要的临床价值。

     

    Abstract:
      Objective   To evaluate the clinical significance of testing the Pre-S1 antigen in HBeAg(-)chronic hepatits Bpatients serum.
      Methods   314 pieces of HBVpositive serum were collected, each was tested separately with both HBVDNA and Pre-S1 antigen by ELISA, including 170 HBeAg(-)pieces and 144 HBeAg(+)pieces.The Pre-S1 antigen and HBV-DNA positive rate was compared between HBeAg(-)and HBeAg(+)groups.
      Results   102(60%)Pre-S1 antigen positive pieces were tested in 170HBeAg(-)patients, the positive ratio was significantly different from HBeAg(+) patients(110 out of 144)(76%)(χ2=9.55, P < 0.005).94% (200 pieces)were also tested HBV-DNA positive in the Pre-S1 positive serum(2.2), its DNA(log)was 5.78±1.94, which could show the significant difference in both positive rate and DNA quantification when compared with Pre-S1 negative patients, with whose DNA positive rate was 84 out of 102 (82%)(χ2=11.45, P < 0.005)and DNA(log)was 4.35±2.33, (t=5.36, P=0.000 1).In the HBeAg(-)group, 90% Pre-S1 serum was also tested with HBV-DNA positive, its DNA(log)was 4.89±2.00, which could show the significant difference in both positive rate and DNA quantification when compared with Pre-S1 negative patients, which DNA positive rate was(75%)(χ2=7.52, P < 0.01)and DNA(log)was 3.77±2.46(t=3.13, P=0.002).Contrastly, in the HBeAg (+)serum groups, although the DNA virus quantification with Pre-S1 positive was higher than that of the Pre-S1 negative group(t=3.73, P < 0.000 1), its total DNA positive rate was shown no difference(χ2=0.627, P > 0.05).
      Conclusion   HBV Pre-S1 antigen is a sensitive serum marker to study the replication of HBV, specially to forecast the state of HBV DNAfor those HBeAg(-)HBV patients.

     

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