Abstract:
Objective To study the maintainable time of humoral immunity against Frencisella tularensis after infection, influence factors and the recessive infection situation in healthy people.
Methods Thirty-one subjects with acute tularemia and the same area healthy people were studied for antibodies to Frencisella tularensis by using Immuno-Chromatographic Assay(ICA)in third week(Jan., 1986), sixth month(July, 1986), second year(1987), third years(1988), sixth year(1991), seventh year(1992), eighth year(1993), ninth year(1994), twentieth year(2005).Special antibody were detected in the cohort study.Titers of > 1B40 were defined as positive.And the subjects were retrospectively studied in 2005.
Results The GMT of subjects decreased from 11890.00(in 1986)to 46.94(in 2005).The rate of decay was 59.1%.Acorrelation was known between the titer of earlier period and that of the latephase(r=0.659, P < 0.05).There were no statistically significant difference between the content of questionnaire and the late-phasetiter.The control group was negative result during 20 years.
Conclusion Special antibody in partial patients can last for a long time with a gradual reducing trend.The titer of the earlier period influence sig nificantly that of the late-phase without other factors.And there is no recessive infection in the healthy people.
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