Abstract: ObjectiveTo explore the relationship between the content of trace elements of geochemical environment and the incidence of birth defects in the high prevalence area of birth defects.MethodThe concentration of 14 kinds elements in the samples of soil,corn,water and hair from the high prevalence areas and the low one in Shanxi province were mensurated with Inductively Couplled Plasma(IGP)machine in the lab.Then the data were statistically analyzed and compared to find the difference of geochemical environment among these areas.ResultsCompared with the samples from the low prevalence area,the concentration of sulfur in the natural environment samples from high prevalence areas was significantly higher,but the concentration of strontium and aluminum were lower.Besides,and there were significant difference between the concentration of Mg,Mn,Mo,Fe,Cu,Ca and Sn in water and corn from the high prevalence birth defects area and that from the low one.ConclusionThe concentration of trace elements in the samples of soil,corn,water and hair from the high birh defects ratio area and the low one has great difference,which can be used to deduce the occurrence of birth defects.