2种燃料燃烧颗粒物致突变性及其联合作用

Mutagenicity by combustion particulates from LPG and coal and their joint action

摘要: 目的比较液化石油气(LPG)燃烧颗粒物和蜂窝煤燃烧颗粒物的致突变性以及二者的联合作用。方法采用Ames法,应用鼠伤寒沙门菌突变型菌株TA 98及其衍生菌株YG 1021和YG 1024进行致突变试验研究,并根据致突变试验结果评价其联合作用。结果2种颗粒物对YG菌株的致突变作用均高于对TA 98的作用;LPG燃烧颗粒物比蜂窝煤燃烧颗粒物的致突变作用更强,前者约相当于后者的8倍;二者的联合作用呈相加类型。结论煤和LPG燃烧颗粒物均具有很强的直接和间接致突变作用,主要致突变作用来源于硝基和胺基多环芳烃,2种颗粒物同时存在可加大致癌风险。

Abstract: ObjectiveTo compare the mutagenicities by combustion particulates from liquefied petroleum gas(LPG)and coal,and to know the model of their joint action.MethodsAmes test was applied.The bacterial strains used were Sal monella typhimurium TA 98 and its two derivation strains YG1021 and YG1024.ResultsThe mutagenicity by LPG combustion particulates was about eight times as high as that by coal.The joint action model of two combustion particulates was additive effect.ConclusionBoth LPG and coal combustion particulates contain strong direct and indirect-acting mutagens,the mutagenicity is mainly induced by nitroarenes and aromatic amines.Concurrence of combustion particulates will increase the risk of carcinogenesis.