Abstract: Objective To summarize the monitoring results and explore the epidemiological feature of leptospirosis from the past years experience.Methods The epidemiological research and monitoring data of leptospirosis in Shandong province were analyzed by retrospective study.Results 133 594 leptospirosis cases were reported from 1964 to 2006,in which there were 81 death cases.Cases occurred in all cities except Bingzhou of Shandong province,and 81 counties,66.92%(89/133)of counties in Shandong,were involved.A concentration of cases occurred in July,A ugust and September.The first epidemiological way was rain,and second was flood.In clinic it primarily manifested as typhoid,and the dominating serogroup was Pomona.The germ-carrying pig was the primary source of infection,and the pig germ-carry rate was closely correlated with leptospirosis.Conclusion The leptospirosis situation was serious before 1980s with the yearly incidence rate of 13.50/100000 while it was controlled after 1990s,the average incidence rate was 0.071/100000 from 1990~2006.