大豆异黄酮对更年期妇女骨密度影响
Effect of soy isoflavone on bone density of menopause females
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摘要: 目的 拟通过人群膳食干预试验,从细胞因子水平研究植物雌激素大豆异黄酮对更年期妇女骨密度的作用。方法 随机双盲法将90名更年期妇女分为大豆异黄酮组观察和安慰剂对照组,每人每天服用大豆异黄酮90mg或者安慰剂,试验期限6个月。超声法测定爱试对象桡骨远端和胫肌中段的骨密度;酶联免疫学方法测定受试对象血清中细胞因子白介素-6(II-6)和肿瘤坏死因子-α(TNF-α)的水平。结果 服用大豆异酮组受试对象的胫骨骨密度增加明显,差异有统计学意义,安慰剂组受试对象骨密度差异无统计学意义;大豆异黄酮组受试对象血清中IL-6和TNF-α的水平在试验结束后均显著降低,差异有统计学意义(P<0.05)。结论 植物雌激素大豆异黄酮可有效增加更年期妇女骨骼密度,其机制可能是通过降低血清中细胞因子IL-6和TNF-α的水平实现的。Abstract: Objective To study the effect of soyisoflavene on menoppause females and their bone mineral density by means of intervention tr ails.Methods 90 menopause females were selected,then divided into two groups,each of them took is of lavone 90mg/d or placebo for 6 months.Their bone mineral of radius and tibia were measured by ultrasoud and IL-6 and TNF-α were measureed by ELISA method.Results The tibia mineral of isoflavone group increased significantly,but that of the control group didn't change;The level of IL-6 and TNF-α of isoflavone group decreased signficantly after trail fin ished.Conclusion Soy isoflav one can increase menopause females'bone mineral and the mechanism maybe is the decreasing the level of IL-6 and TNF-α.
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