Abstract: Objective To know the uric acid level in Han and Uygur ethnic and the prevalence of hyperuricemia of two ethicities in Xinjiang.Methods From January to December 2005,the blood samples were collected for serum uric acid(SUA) detection among the population including 5560 subjects aged 20 to 80 years.Results The mean of SUA in Han ethnicity was 344.23±103.22 mol/L(393.08±86.97 mol/L for men and 259.83±69.89 mol/L for women),and in Uygur ethnic was 310.68±106.85 mol/L(364.09±99.52 mol/L in men and 246.42±75.44 mol/L in women).Han ethnic was hig her than Uygur ethnic and man was higher than woman(P<0.05)in two ethnicities.The prevalence of hyperuricemia in Han ethnic was 27.3%(37.7% in men and 9.5% in women)and Uygur ethnic was 17.5%(27.4% in man and 5.7% in women).The average age of hyperuricmia occured for Han was 38.26 year in men and 42.94 year in women,and for Uygur ethnic was 46.42 year in men and 51.33 year in women.Conclusion The uric acid level and the prevalence of hyperuricmia of Han were hig her than Uygur ethnic population in Urumchi,and were higher than other place in China.