Abstract: Objective To understand the situation of construction and application of information system in the CDCs of Guang dong Province on municipal and county level and put for ward counter measure.Methods Adesigned questio nnaire was answered by 115 CDCs.Spss 10.1 was used to analyze the data.Results 110 CDCs finished the investigation.Of the all staff members in the 110 CDCs,45.2% had a computer,50.5% had established a local networ k,27.1% had a website,11.5% had a office automatic system,99.1% had connected with Internet,76.9% had installed a special anti-virus soft ware 100% had applied the China Disease Control and Prevention Information System.18.0%,19.0% and 19.8% had developed and applied the Disease Surveillance Information System,the Sanitation Surveillance Information System and the Health Lab Information Management System on their own,respectively.44.1%,37.9% and 33.7% had applied the Physical Examination Information Management System,the Financial Management System,and the Secondary Education Information Management System respectively.52.8% of softw are were commodity softw are bought from companies,39.1% were developed by company according to the need of the CDC.Of the software used in the professional departments,65.7% were developed by a entrusted company.Of the software used in the management department,78.1% were mar ketable softw are.Conclusion The development of computer information system in the CDCs in Guangdong province was in the pr imary stage and should be speed up,so as to catch up with the middle developed countries in the year 2010.