Abstract: Objective To explore the associat ion between isolated systolic hypertension and the interaction between serumiron and risk factors.Methods the population of Harbin New spaper Office were selected as subjects to conduct the cross-sectional study by cluster sampling.All subjects were interviewed with questionnaire and their blood pressure,stature,weight,waist circumference,hip circumference were measured and the status of smoking and drinking were investigated.Results There was significant difference in age between the isolated systolic hypertensives and normotensives(P<0.01),but not in gender(P>0.05).The prevalence of alcohol drinking and smoking had no significant difference in two groups(P>0.05).The average levels of TG,TC,LDL-c,fasting plasma glucose(FPG)in isolated systolic hyper tensives were higher than in the normotensives(P<0.01).Both the body mass index(BMI)and ratio of waist to hip cir cumference(WHR)were significantly higher in the isolated systolic hypertensives than in the normotensives(P<0.01).Positive interaction between serumiron and over weight was found,it was similar in serumiron and fasting plasma glucose(FPG).This interaction was confined to no confounding factors being adjusted.Conclusion Serumiron was not associated with isolated systolic hypertension.