Abstract: Objective To evaluate the antiox idation of Laurencia extract(LET)on rats after alcohol exposure.Methods Sixty male Wistar rats were randomly assig ned to six groups:group A(placebo group)was orally given with distilled water and Group B with alcohol of 7.2g/kg·d;Group C,D and E was or ally supplemented with LET of 25,50 and 100 mg/(kg·d) respectively;Group F(positive control)was fed with diammonium glycyrrhizinate of 200 mg/(kg·d).All rats were treated for 7 days.The blood and hepatic tissue of the rats were collected to measure SOD and GSH-Px.The ultrastructures were studied.Results Compared with other groups,Group B showed severe hepatic injury with abnormally lower SOD(218.75±10.24)and GSH-Px(953.56±341.84)(P<0.05),as well as hepatocyte fatty degeneration.Rats fed with LET and diammonium glycyr rhizinate experienced mild abnor malities in the blood tests and hepatic injury.Conclusion LET may raise antiox idase and improve ultrastructures injury after alcohol exposure.