Abstract: Objective Select corr elative items to develop the multidimensional sub-health questionnaire of adolescents (MSQA)based on the situation of China.Methods To establish initial quest ionnaire based on comprehensive literature referring and expert consultation and chose 4 626 junior and high school students and 1 842 academicians as samples to take the preliminary test.T-test,Pearson cor relation analysis and factor analysis were used to select the items.Results Based on the item analysis,the MSQA established was composed of 71 items which including 32 items in physical sub-health part and 39 items in psychological part.Conclusion the MSQA is developed and more reliability and validity analysis is needed.