Abstract: Objective To study and analyze the effect of lycopene on osteopor osis of ovariectomized rat model.Methods Seventy-two 15-week-old SD rats were divided into six groups,included control group and five ovariectomized model groups.The model groups were fed with different-dose lycopene10,15,20 mg/(kg·bw)for 12 weeks.Then related indexes including length bone mineral density,bone mineral,serumestradiol,sertum AL P and uterus index were analy zed.Results Compared with model group,three different dose groups and nilestriol1.05mg/(kg·bw)group showed increased bone mineral density,bone mineral,serumestradiol and uter us index,but decr eased serum A LP(P<0.05).Conclusion As a female sex hormone-like component,lycopene may amelior ate the bone quality and inhibit osteoporosis in ovariecto mized rat.