Abstract: Objective To expolre the characteristic,cause and risk factors of road injury among motorcycle drivers and to give the feasible comments for motorcycle road injury controll.Methods Case-control study was used.From January 2006 to January 2007,350 drivers who had ex perienced a motorcycle crash in Qingx iu district,Nanning city were recruited and 350 normal motorcycle drivers were matched for the time and the site of the injury.Results Single factor logistic regression showed that education,age,cont inuous driving time were associated with road traffic injury.Multiple factors non-conditional logistic regression showed increased risk factors of education(OR=1.619,95%CI=1.154~2.272),continuously drive time (OR=4.874,95%CI=3.019~7.868),cellphone use(OR=2.109,95%CI=1.128~3.944),license(OR=4.099,95% CI=1.856~9.054),driving age(OR=2.307,95%CI=1.358~3.920),overspeed(OR=1.834,95%CI=1.300~2.585),rushing thered line(OR=1.729,95%CI=1.233~2.423).Conclusion Traffic safe consciousness,driving skills and improper driving behaviors were related to road traffic injury.It is necessary to carry out continous traffic security educcation to the drivers.