Abstract: Objective To study anti-inflammatory effect of different chemical components of Isodon excisus(Maxim)Kudo.Methods Models of xylene induced ear edema and acetic acid induced peritonitis in mice were adopted to obser veanti-inflammatory effect of different chemical components of Isodon excisus(Maxim)Kudo.Results Water extracts of Isodon excisus(Maxim)Kudo(ip 2g/k,5g/kg)and alcohol extracts of Isodon excisus(Maxim)Kudo(ip 5g/kg),Isodon excisus (Maxim)Kudo diterpenoids(ip 5g/kg),Isodon excisus(Maxim)Kudo polysaccharides(ip 5g/kg)could significantly inhibit the mice ear edema and the percentage of inhibition was 40.09%,87.35%,37.95%,40.09%,29.53%,respectively.Water extracts of Isodon excisus(Maxim)Kudo(ip 2g/kg,5g/kg)and alcohol extracts of Isodon excisus(Maxim)Kudo(ip 5g/kg),Isodon excisus(Maxim)Kudo Diterpenoids(ip 5g/kg),Isodon excisus(Maxim)Kudo polysaccharides(ip 5g/kg) could significantly inhibit the peritonitis in mouse induced by acetic acid and the percentage of inhibition was 40.28%,66.45%,43.07%,39.71%,33.08%,respectively.Conclusion Isodon excisus(Maxim)Kudo could significantly inhibit the mice earedema induced by xylene and the peritonitis in mouse induced by aceticacid.