Abstract: Objective To evaluate the reliability and validity of Multidimensional Sub-health Questionnaire of A dolescents(MSQA).Methods A total of 7.04 middle school students,feshman,sophomore and jumior were randomly selected from Bengbu city using cluster sampling.One hundred and twenty eight students were re-tested with the MSQA at interval of 2 weeks,85 students were administered SCL-90 and CMI as criteria test.the data was analyzed with the methods of Pearson correlation analysis and factor analysis.Results Test-retest correlation coefficient,Cronbach A coefficient and split-half reliability coefficient of the questionnaire was 0.868,0.957 6,0.942 0,respectively.Taking SCL-90 and CMI as criterion,the criterion-related validity was 01636,01649,respectively.Conclusion the MSQA is credible,effective and sensitive,could serve as a sub-healthy evaluat ion tools for young pepole.