Abstract: Objective To compare the differet expressions of 3-hydroxy-3-methyl glutary l-CoA,synthase 2 (HMGCS2)in kidney bewteen stroke prone spon taneously hypertensive rat(SHRSP)and spontaneo usly hypertensive rat (SHR)strains and explore its antiox idative role.Methods Five male SHRSP and five male SHR at the age of 2 months were randomly chosen.The expressions of HMGCS2,cata lase and phosphory lating signal of prote in kinase B(Akt)pathway were evaluated by mimunoblotting analysis.The level of malond ialdehyde(MDA)was also measured.Results Lower renal HMGCS2 expre ssion(6398±658.128 v s16516.67±1321.855,P<0.05),higher MDA level(0.738±0.175 U/rag prot vs 0.330±0.032 U/mg prot,P<0.05)and higher Akt phosphorylation signal(1.909±0.124 vs 0.229±0.071,P<0.05)in SHRSP than those of in SHR were observed.Conclusion The different expression of renal HMGCS2 between SHRSP and SHR may be partially responsible for the an tioxida tive property.