Abstract: Objective To explore the protective effect of Pteridium aquilimun flavanone extract on ethyl alcohol hepatic toxicity in mice and its possible mechanism.Methods Sixty mice were random divided into 5 groups: low,mfiddle and high dose groups,alcohol model group and noun al control group.After gavaged with flavanone extract for 45 days,the low,mfiddle and high dose groups were gavaged with 50% ethyl alcohol The ethyl alcohol model group were first gavaged with pure water continuously for 45 days,then gavaged with 50% ethyl alcohol.The nromal control group were gavaged with pure water for 45 days.The CPT in blood serum,the TC and the MDA in liver and the liver index were deteun fined by colorin etric analysis.Resalts Compared with the ethyl alcohol model group,low dose Pteridium aquilinum flavanone could obviously reduce the CTP in blood seiwn and the TC in liver(P<0.05).Middle dose Pteridium aquilinum flavanone extinct obviously reduced the CTP in blood seiwn and the TC in liver(P<0.0l) and the MDA in liver(P<0.05).High dose Pteridium aquilinum flavanone extract obviously reduced the CPT in blood seiwn and the TC in liver(P<0.05) and reduced the MDA in liver(P<0.01).The liver index of the noun al control was the lowest.The Pteridimn aquilinum flavanone extract could not change the increased liver index to nounal level.Conclusion Pteridium aquilinum flavanoe extract has protective effect on ethyl alcohol hepatic toxisity in mice.