Abstract: ObjectiveTo analyze the epidemio logical trend of hepatitis B,liver cirrhosis and liver cancer during 1990 to 2007 in Shandong province,and to evaluate the effectiveness of hepatitis B prevention and control measures,so as to provide the evidence for policy-making.MethodsBased on the routine incidence data of hepatitis B,mortality data of hepatitis B,liver cirrhosis,liver cancer and demographic data,the incidence rate,mortality rate and age-specific mortality rate were calculated and analyzed with simple linear regression model.ResultsA total of 437094 cases of hepatitis B were reported during 1990-2007 with an average yearly morbidity of 27.32 per 100 000 population and a decreased trend for the 0-9 year-old children.At the same time,the adjusted mortality rate for hepatitis Band liver cirrhosis showed a decreased tendency signifcantly and the combined mortality rate decreased from 17.55/100 000 in 1990 to 4.01/100 000 in 2007.While there was a steady tendency for liver cancer(P=0.999 8).ConclusionThe good immunization work of hepatitis B vaccine can lower the incidence of hepatitis B for the target population and the mortality rates of related liver cirrhosis and liver cancer.