Abstract: ObjectiveTo explore the relationship between glycometabolism andpancreatic B cell in type Ⅱ diabetes.MethodsFifty-one patients with newly diagnosed type Ⅱ diabetes and forty-eight noun alpersons were selected.The fasting blood glucose, insulin, C-peptide and HbA₁c were deteunfined with radioinm unoassay, enzyme-linked inmunosorbent assay and inmune nephelometry.ResultsFor newly diagnosed type Ⅱ diabetes patients, the values of fasting C-peptide, insulin, HbA₁c and fasting blood glucose were higher than that of the nounal(P<0.01),and HbA₁c and fasting blood glucose were positively correlated C lucose content changed wih diversification of C-peptide, insulin and HbA₁c.Conclusion The value of fasting C-peptide, blood glucose, insulin and HbA₁c of type Ⅱ diabetes patients are higher than that of the nounal D fiver sification of C-peptide, insulin, HbA₁c can cause blood glucose elevation.