Abstract: ObjectiveTo investigate the distribution of congenital heart diseases(CHD)in children aged 4-17 in Hainan region of Qinghai province.MethodsHeart auscultation and echocardiography examination on 53827 children from Hainan region of Qinghai province were conducted.ResultsThe overall morbidity of CHD was 5.68‰,with 3.95‰ in males and 7.66‰ in females.Significant difference of prevalence rates was found between different sex(χ²=32.681,P<0.001).Atrial septal defect(32.35%)was noticed as the most common lesion.The next was ventricular septal defects,patent ductus arteriosus and others with significant difference(χ²=40.566,P<0.001).Morbidity rates in different regions were 8.90‰ in Xinghai,7.20‰ in Tongde,5.88‰ in Guinan,5.78‰ in Gonghe,and 3.80‰ in Guide.There was no significant difference in morbidity rates with the increase of altitude.Morbidity rates in different ethnic groups were as follows:6.37‰ in Han,3.70‰ in Mongolian,6.42‰ in Tu,4.05‰ in Tibetan,7.28‰ in Hui.Tibetan had a different morbidity rate compared to Han and Hui(χ²=13.414,P<0.001;χ²=10.904,P<0.005).ConclusionThere were significant regional,sex and ethnic differences in the morbidity of CHD in Hainan region of Qinghai province.