Abstract: ObjectiveTo explore HIV and syphilis infection among drug users in a detoxification center in Shenzhen.MethodsA face to face questionnaire investigation was conducted among 357 drug users, and the subjects were tested for HIV antibody and syphilis RPR.ResultsThe HIV positive rate was 2.24% (8/357) and the syphilis positive rate was 10.08% (36/357) among the subjects There was no statistical difference in HIV positive rate between the male and the fema1e(P=0.9738),but the infection rate for syphilis in women was significantly higher than in men(P<0.0001).There were no statistical difference in positive rate for HIV and syphilis in drug users with different way of drug using(P₁= 0.6756, P₂=0.8441).In the drug users, the rates of sharing needle and commercial sexual behavior were 20.45%, 15.13%,respectively.Only 11.11% of the subjects with commerial sexual behavior used condom every time.The average age of the drug users was 29.4 years old, and the youngestwas 12 5.88% of the drug users were from local area, the rest were from other places.ConclusionThe age of drug users tends to be younger and most of them are immigrants with high risk behavior of HIV and STD.The management of migmntworkers and health education on STD in adolescents should be enhanced.