Abstract: ObjectiveTo explore the effects of exercise on the expression of iron regulatory protein-2(IRP-2)gene in brain aging mice.MethodsForty mice were randomly divided into four groups:control group,exercise group,brain aging group,brain aging+exercise group.The experimental duration was 10 weeks.Morris water maze test was used to measure the learning and memory ability.Reverse transcription polymerase chain reaction(RT-PCR)was used to detect the brain IRP-2 gene expression.ResultsIRP-2 gene expression decreased in brain aging mice(0.738±0.221)and reached to the extent of statistical significance(P<0.05).There was no difference in IRP-2 gene expression between exercise group(2.595±0.822)and control group(3.925±2.357).Compared with the control group,there was no remarkable effect in brain aging+exercise group(2.938±0.468),but the IRP-2 gene expression in brain aging+exercise group was higher than that in brain aging group(P<0.05).ConclusionExercise can prevent the decreasing of IRP-2 gene expression in brain aging mice.