Abstract: ObjectiveTo test the association of insulin induced gene 2(INSIG2)rs7566605 polym prphism with obesity and the metabolic abnormalities in children and adolescents in China.MethodsOrerall 1 103 students aged 7 to 182 year-old were sellected in Haidian district,Beijing.The body and metabolic indexes were measured and the rs7566605 polymorohism was genotyped.ResultsThe mutation rate of rs7566605(G>C)in the children and adolescents was 35.56% to 37.06%,similar to those of European and the United States population.The differences of genotype and allele frequencies in normal weight,overweight and obese group were not significant(P>0.05).Stratified analyses showed that the CC genotype carriers in overweight group had higher skinfold thickness and body fat percentage than that of GG/GC geno type(P<0.05).Average level of triglyce ride(TG)of CCgenotype carriers was 0.21mmol/L and higher than that of GG/GC genotype in obese group(P=0.014).ConclusionThere was no association between INSIG2 gene rs7566605 polym orghism and childhood overweight or obesity in China.But the polymorphism may have some influence on TG accumulation and body fat content in overweight or obese children and adolescents in China.