Abstract: ObjectiveTo study the effect of enteromoipha prolifera polysaccharide(EP) on blood lipid and anti-oxidize in experinental high blood lipid rats.MethodsAdult SD rats were randomly divided into five groups according to the level of total seiwn cholesterol and weight High fat and high cholesterol diet with different doses of polysaccharide(low, middle and high) were given to the rats for 6 weeks The TC, TG, LDL-C, SOD, GSH-Px, MDA in the seiwn were measured.Liver tissues were observel with optical microscope.ResultsEP could decrease serum TC, TG, LDL-C, MDA remarkably(P<0.01) with the decreasing rate of 41.7%,79.3%,59.6% and 55.0% respectively.The middle and high does of EP could lower AI at 79.7%.All doses of EP could increase the levels of HDL-C, SOD and GSH-Px(P<0.01) with the highest rates of 66.6%,63.8% and 48.9%.The degeneration of liver cell of hyperlipidem is rat was decreased by EP treatment.ConclusionEP shows significant effect of anti-hyperlipidaemia, anti-oxidization and prevention of fatty liver in the hypereholesterolem is rats.