Abstract: ObjectiveTo research the protective effect of three xanthone glucosides from Halenia corniculata on chemical hepatic injury in mice.MethodsThe chemical hepatic injury was induced by CC14 in mice as the model to study the morphologic changes of liver and the liver coefficient, serum ALT,AST activity and liver glycogen level.ResultsCompared with the model group,the high dose(10 mg·ml^-1)xanthone glucosides showed effects of restoring of liver tissue,reducing the liver coefficient, serum ALT and AST activity,inc reasing the liver glycogen level(P<0.01).The medium dose (5 mg·ml)xanthone glucosides increased the liver glycogen level(P<0.05)and induced significant alterations of other in dexes compared with model group(P<0.01).In low dose(1 mg/ml),Btype xanthone glucoside reduced the liver coefficient and serum AST activity(P<0.05).The Ctype xanthone glucoside significantly reduced the serum AST activity(P<0.01)and inhibited the rise of the serum ALT(P<0.05).ConclusionThe results indicate that three xanthone glucosides from Helenia corniculata could protect the liver against chemical injury in dose effect manner in mice.