Abstract: ObjectiveTo understand the prevalence and inpactfactors of permenopausal and depressive symptom sinurban and rural women of Hebei for improving permenopausal women's health and quality of life.MethodsWith stratified random sampling, 700 women aged 45-55 years were selected from 7 urban and rural regions of Hebei province Basic information questionnaire, Kuppeun an score sheet and seft-frating depression scale (SDS)were adopted.ResultsAmong the subjects, 95.22% reported permenopausal syndrome; 31.26% had depression.The women living in the town, and without job, with illness partner, divorced, with poor marriage quality, with poor living condition, having bad neighborhood or colleague relationship, with menstrual disorder, without social or family support had higher rate of permenopausal syndrome with significant difference(P<0.05 or P<0.01).The women with permenopausal syndrom a had significant higher rate of depression.ConclusionThe incidence of permenopausal syndroma and depression were higher among women of 45-55 years in Hebei urban and rural areas and the influencing factors were complex.