Abstract: ObjectiveTo study the virological and inmunological effcacy of HAART among Chinese HIV/ASS patients and its influence of drug resistance mutations.MethodsViral load, CD4⁺ Tlymphocytes count and drug resistance genotype were detected in patients after two reginens treatment.ResultsUndetectable viral load level and CD4⁺ Tbmphocytes maintenance were achieved among a part of HIV/AIDS patients, but drug resistance mutations happened during the two reginens.High drug resistance mutation rates of D4T/ddI/NVP, AZT/ddI/NVP were 19.7%,16.2% in 2005, and 19.4%,19.5% in 2006.ConclusionExpected efficacy was achieved in Chinese HIV/ASS patients But the high prevalence of drug resistance mutations against reverse transcriptase inhibitors, crossing drug resistance, and multi-drug resistance suggest that more attention should be paid to the drug resistance mutation detection, treatment standardization.